Allantoin occurs naturally in the body, but can also be derived from the root of the Comfrey plant or Chamomile, or produced synthetically. It is used in skincare for its ability to promote wound healing and healthy tissue growth, by stimulating the fibroblasts in the dermis to produce collagen and elastin fibres, essential tissues for skin regeneration and healing. Allantoin has also been shown to have soothing and anti-irritant properties, which is thought to be down to its ability to form complexes with irritating agents, thus preventing them from activating inflammatory mechanisms within the skin.