Histidine is a semi-essential amino acid which the body does not produce. When synthetically produced is known for being more hydrating to the skin.

Amino acids are a class of ingredients. They can also be found on ingredients lists as acetyl glucosamine,acetyl tyrosinamide, alanine, arginine hcl, arginine pca, histidine, isoleucine, lysine, phenylalanine, proline, serine, taurine, threonine and valine and yeast amino acids.

Renude

dryness

dullness

fine_lines

impaired_barrier

roughness

This overnight treatment is full of ingredients to hydrate the skin and support the skin barrier, so is a perfect add-on to your daily routine, to nourish your dry skin and leave it plump & hydrated.

Amino acids are the small building blocks that make up peptides, and proteins. Each amino acid has a unique structure, and as such plays a specific role within the body. There are around 20 different types considered to be most important for human health. In the outer layer of the skin, the stratum corneum, they are present in the ‘natural moisturising factors’, our skin’s own moisturising mechanism, and they help to support water transport between skin cells to keep our surface smooth and hydrated.

alanine

Arginine is an amino acid which occurs naturally within the human body. It is a popular ingredient in skincare for a number of reasons; it offers antioxidant protection, it hydrates the skin by stimulating the body's own production of humectants like urea and it can also repair visible skin damage.

arginine

ceramide ap

Ceramides are long chains of lipids, which occur naturally within the epidermis. Their function is to hold the skin cells together by creating a barrier against water-loss from the inside-out, and external aggressors from the outside-in. They make up almost 50% of our skins composition, but they can be depleted by UV, free radicals & pollution, and their production also naturally slows with age. This leads to an impaired skin barrier, which results in dry, rough skin with more visible wrinkling and redness. Applying ceramides topically can increase the levels of ceramides in the epidermis, and therefore supports the natural healthy functioning of the skin.

ceramide eop

ceramide np

Cholesterol is a fatty acid which occurs naturally in the skin’s lipid barrier. Applying cholesterol topically supports the skin barrier, reducing trans-epidermal water loss (TEWL), and maintaining healthy skin functioning. Strengthening this lipid barrier also leads to improved skin hydration, which in turn leads to smoother, plumper, younger-looking skin.

cholesterol

Our outer layer of the skin, the stratum corneum, has a multilamellar structure (essentially a fine membrane), made up of lipids (fats), to form a non-permeable barrier. This keeps water inside the skin, and acts as the first defense against external aggressors. The lipids which make up the majority of this are known as ceramides, which are produced naturally in the body from a range of other naturally-occurring lipids, which we class here as essential lipids (not the same as essential fatty acids, which are deemed ‘essential’ as the body cannot produce these naturally.) Using these lipids in skincare helps to support the natural skin barrier, preventing water-loss to keep skin hydrated and balanced.

glycine

histidine

Acetyl Glucosamine is an amino acid sugar

isoleucine

Phytosphingosine (PS) is a lipid which naturally occurs in the stratum corneum (the top, visible layer of our epidermis). This acts as a precursor for ceramide synthesis, meaning it encourages the skin to produce ceramides naturally.

Studies have also shown PS to offer anti-acne benefits, it is believed by reinforcing the protective barrier, and therefore reducing specific abnormalities in the skin functioning that lead to acne (invading inflammatory bacteria, increased keratinization, increased sebaceous gland activity).

phytosphingosine

proline

serine

Sodium hyaluronate is the sodium salt of hyaluronic acid (a polysaccharide which occurs naturally in the body), created to improve the ingredient stability. It works as an extremely powerful humectant, able to attract 1000x its own weight in water, to immediately plump and hydrate the area it is applied to. The body’s own production of hyaluronic acid slows with age, so supplementing this ingredient in topical formulations helps to support the skin’s natural moisture-binding, anti-ageing mechanisms.

sodium hyaluronate

Hyaluronic acid is a polysaccharide which occurs naturally in the body. Hyaluronic acid works as an extremely powerful humectant, able to attract 1000x its own weight in water, to immediately plump and hydrate the area it is applied to. The body’s own production of hyaluronic acid slows with age, so supplementing this ingredient in topical formulations helps to support the skin’s natural moisture-binding, anti-ageing mechanisms.

Sodium PCA is the sodium salt of pyrrolidone carboxylic acid (PCA), which is found naturally in the body, and in the skin’s natural moisturising factor (NMF). PCA acts as a humectant, meaning it draws water to it, plumping and hydrating the area. The skin’s NMF ensures adequate hydration of the stratum corneum, which also works to support the overall barrier function of the skin, regulating trans-epidermal water loss (TEWL). Including Sodium PCA in skincare supports this natural mechanism of the skin.

sodium pca

Natural moisturising factor (NMF) is a substance produced by the body, made up of minerals, lactate, urea, amino acids & humectants, which coats the surface skin cells to keep them moisturised. NMF increases the skin’s ability to retain moisture, which results in more hydrated, plump, smoother skin.

Squalane is a natural substance usually derived from olives. It is structurally very similar to our skin’s own sebum, so is a great ingredient to support our own natural skin processes. In drier skin, which is naturally lacking in natural sebum, it helps to support the skin barrier to prevent water loss, which results in more hydrated, smooth and plump skin. Due to its sebum-mimicking structure, it is non-comedogenic, meaning it won’t cause breakouts, so is also suitable for oily and acne-prone skin. It can be a great option to reduce any over-stimulation of the sebaceous glands, which can occur with excess cleansing (and make breakouts worse). It also works to support the skin barrier to combat any drying effects caused by ingredients commonly associated with acne treatment, so is a great ingredient for all skin types.

squalane

threonine

valine

Forget complicated beauty jargon, The Inkey List are a no-funny-business brand who harness the power of science for effective skincare. Their Ceramide Night Treatment works to replicate the naturally occurring Ceramides in your skin, amplifying its ability to retain moisture overnight. Hydrated skin is happy skin, appearing smoother, plumper and softer. Including one of the most sought-after ingredients, hyaluronic acid, this mask offers pure hydration, locking moisture into your skin cells. What’s more, this formula fights signs of premature ageing, helping your complexion to stay youthful and supple.

elasticity

wrinkles

I have chosen this peptide-based serum to target the ageing concerns you mention. Loaded with various anti-ageing peptides, this works to reduce wrinkles and improve skin firmness and smoothness.

Acetylarginyltryptophyl Diphenylglycine is a synthetic tetrapeptide used in skincare for its firming abilities. It works by inhibiting the enzyme elastase, which breaks down elastin in the skin (the protein responsible for skin firmness and elasticity). This reduction in elastase allows for higher levels of elastin in the skin, which in turn leads to skin that looks firmer, tighter and restructured.

acetylarginyltryptophyl diphenylglycine

Many peptides function as anti-ageing ingredients in skincare, due to their ability to fit specific receptors in the body to trigger anti-ageing responses. This includes mechanisms like collagen production, cell regeneration or even blocking muscle contractions to smooth expression lines. Peptides are made up of amino acids, and are unique in shape, with a huge variety available to target specific responses in the body.

acetyl hexapeptide

Allantoin occurs naturally in the body, but can also be derived from the root of the Comfrey plant or Chamomile, or produced synthetically. It is used in skincare for its ability to promote wound healing and healthy tissue growth, by stimulating the fibroblasts in the dermis to produce collagen and elastin fibres, essential tissues for skin regeneration and healing. Allantoin has also been shown to have soothing and anti-irritant properties, which is thought to be down to its ability to form complexes with irritating agents, thus preventing them from activating inflammatory mechanisms within the skin.

allantoin

dipeptide diaminobutyroyl benzylamide diacetate

Lactococcus Ferment Lysate is a post-biotic ingredient derived from Gram-positive bacteria, Lactococcus lactis. It is used in skincare for its ability to increase the speed of epidermal growth, leading to a thicker stratum corneum (outermost layer of the skin), and in turn better barrier function. This is seen as healthier-looking, more hydrated and supple skin.

lactococcus ferment lysate

Probiotics can be defined as living bacteria which are good for the skin, and are useful to include in skincare formulations in order to populate a healthy microbiome (the ecosystem of bacteria on the skin). A diverse breadth in the strains of bacteria living on the skin results in a healthy microbiome, and some early research has linked certain imbalances in this microbiome to skin conditions such as acne, ezcema and psoriasis.

palmitoyl tetrapeptide

pentapeptide

phenylalanine

Sodium Hyaluronate crosspolymer is a modified version of Hyaluronic acid, with additional polymers added to it to slow skin penetration, keeping it in the upper layers of the epidermis for longer to provide surface hydration.

sodium hyaluronate crosspolymer

This formula combines a comprehensive array of studied technologies to target multiple signs of aging at once. The technologies are Matrixyl™ 3000 peptide complex (with palmitoyl tetrapeptide-7), Matrixyl™ synthe'6™ peptide complex (with palmitoyl tripeptide-38), SYN™-AKE peptide complex (with dipeptide diaminobutyroyl benzylamide diacetate), Relistase peptide complex (with acetylarginyltryptophyl diphenylglycine), ARGIRELOX™ peptide complex (with acetyl hexapeptide-8, pentapeptide-18), Probiotic complex (with lactococcus lactis lysate), in a base of 11 skin-friendly amino acids and multiple hyaluronic acid complexes. The total concentration of these technologies in the formula by weight is 25.1%.

Unfragranced

Vegan

dehydration

This simple moisturiser is a great option for you to add hydration to the skin and support the natural lipid barrier without clogging pores. It is packed with ingredients which occur as part of the natural moisturising layer of the skin, to help support surface hydration and keep skin healthy.

Glycerin is a humectant present in all natural lipids. It works to attract water molecules towards it, plumping & hydrating the applied area, resulting in smooth, soft, hydrated skin. It is one of the most widely used humectants in skincare, due to it’s high performance and broad availability (making it very cost-effective). Recent research has shown that it’s ability to penetrate the layers of the skin is superior to that of low molecular weight hyaluronic acid, making it a brilliant choice for overall skin hydration, and suitable for all skin types.

glycerin

Linoleic is an Omega 6 essential fatty acid (EFA), found in many plant oils: corn, safflower & sunflower. Linoleic acid forms the fatty acid based of Ceramides EOH, EOS and EOP, which are essential for the normal functioning of the skin barrier. Applying linoleic acid topically helps to support ceramide functioning within the skin, leading to improved skin hydration and smoothness.

Research also shows that sebum in acne-prone skin can be lacking in Omega 6 (with too much Omega 3), so there is evidence to suggest applying this topically can help to balance the sebum composition and in turn reduce acne lesions.

linoleic acid

Lysine is used in skincare to treat hyperpigmentation & post-inflammatory acne scarring.

lysine

Sodium lactate is a salt produced by the fermentation of lactic acid. It acts as a humectant in the skin, drawing water molecules from the atmosphere towards it to plump and hydrate. It is present in the skin’s natural moisturising factor (NMF), as both sodium and lactate. Studies have shown that lactate levels in the stratum corneum directly correlate with the hydration levels within the skin, with low levels resulting in dry, rough, flaky skin. Applying this ingredient topically helps the natural water-binding capacity of the epidermis, resulting in smoother, softer, more hydrated skin.

sodium lactate

Urea is humectant ingredient found in the skin’s natural moisturising factor (NMF), making up around 7-8% of the total composition. Its humectant properties mean it can bind to water molecules in the atmosphere, drawing them to it, and in turn plumping and hydrating the skin. Research also shows that Urea has a mild exfoliating action on the skin, encouraging the removal of dead cells which results in smoother, healthier, more hydrated skin.

urea

Effectively hydrate skin with The Ordinary Natural Moisturising Factors + HA; a non-greasy moisturiser that supplements skin with a selection of Natural Moisturising Factors to help protect and nourish. Glycerine and molecular weight Hyaluronic Acid quench dryness, while essential amino and fatty acids replenish the lipid layer for improved water retention. A complex blend of phospholipids, triglycerides and saccharides ensure long-lasting results for skin that feels smooth, soft and supple.

We love that this perfect lightweight, yet hydrating moisturiser can be used on all skin types. The oil-free yet hydrating formula is enriched with Hyaluronic Acid to plump and moisturise the skin without feeling heavy. As well as being cruelty-free and vegan, The Ordinary Natural Moisturising Factors + HA is also free from alcohol, oil, silicone, nuts and gluten. Ideal for all skin types but especially those with a drier complexion, it features a blend of phospholipids, triglycerides and saccharides keep the outer layer of the skin protected and well-hydrated for a soft, supple feel.

Histidine

What is Histidine?

What does Histidine do?

Who is Histidine good for?

Who should avoid Histidine?

Histidine

What is Histidine?

What does Histidine do?

Who is Histidine good for?

Who should avoid Histidine?

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